The classic personal account of Watson and Crick’s groundbreaking discovery of the structure of DNA, now with an introduction by Sylvia Nasar, author of A Beautiful Mind. By identifying the structure of DNA, the molecule of life, Francis Crick and James Watson revolutionized biochemistry and won themselves a Nobel Prize. At the time, Watson was only twenty-four, a young scientist hungry to make his mark. His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of science’s greatest mysteries gives a dazzlingly clear picture of a world of brilliant scientists with great gifts, very human ambitions, and bitter rivalries. With humility unspoiled by false modesty, Watson relates his and Crick’s desperate efforts to beat Linus Pauling to the Holy Grail of life sciences, the identification of the basic building block of life. Never has a scientist been so truthful in capturing in words the flavor of his work.
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Bridging law, genetics, and statistics, this book is an authoritative history of the long and tortuous process by which DNA science has been integrated into the American legal system. In a history both scientifically sophisticated and comprehensible to the nonspecialist, David Kaye weaves together molecular biology, population genetics, the legal rules of evidence, and theories of statistical reasoning as he describes the struggles between prosecutors and defense counsel over the admissibility of genetic proof of identity. Combining scientific exposition with stories of criminal investigations, scientific and legal hubris, and distortions on all sides, Kaye shows how the adversary system exacerbated divisions among scientists, how lawyers and experts obfuscated some issues and clarified others, how probability and statistics were manipulated and misunderstood, and how the need to convince lay judges influenced the scientific research. Looking to the future, Kaye uses probability theory to clarify legal concepts of relevance and probative value, and describes alternatives to race-based DNA profile frequencies. Essential reading for lawyers, judges, and expert witnesses in DNA cases, The Double Helix and the Law of Evidence is an informative and provocative contribution to the interdisciplinary study of law and science.
Endfire antennas develop their maximum gain when the phase velocity of the surface wave traveling along the structure is adjusted to its optimum value determined as a function of antenna length and operating frequency. These antennas usually have a relatively small pattern bandwidth and, if maximum gain is desired, can be used over only a small frequency range. The antennas described in this paper inaugurate a new class of antennas that are tunable for maximum gain in the endfire direction over a wide frequency range; tuning is accomplished by changing the phase velocity continuously or in prescribed steps. Such antennas include certain spatial configurations of the double helix (a novel type of endfire antenna) and its artificical and natural dielectric variants. Useful structures are obtained through parallel displacement of two juxtaposed elements or angular displacement of a scissors arrangement. Model measurements show that maximum gain can be obtained over a frequency range of more than 2:1. Tuning effects are illustrated in detail by means of nearfield plots of a tuned dielectric antenna. (Author).
In his 1968 memoir, The Double Helix (Readers Union, 1969), the brash young scientist James Watson chronicled the drama of the race to identify the structure of DNA, a discovery that would usher in the era of modern molecular biology. After half a century, the implications of the double helix keep rippling outward; the tools of molecular biology have forever transformed the life sciences and medicine. The Annotated and Illustrated Double Helix adds new richness to the account of the momentous events that led the charge.
The story of the most significant biological breakthrough of the century - the discovery of the structure of DNA. 'It is a strange model and embodies several unusual features. However, since DNA is an unusual substance, we are not hesitant in being bold' By elucidating the structure of DNA, the molecule underlying all life, Francis Crick and James Watson revolutionised biochemistry. At the time, Watson was only 24. His uncompromisingly honest account of those heady days lifts the lid on the real world of great scientists, with their very human faults and foibles, their petty rivalries and driving ambition. Above all, he captures the extraordinary excitement of their desperate efforts to beat their rivals at King's College to the solution to one of the great enigmas of the life sciences.
Written by a noted historian of science, this in-depth account traces how Watson and Crick achieved one of science's most dramatic feats: their 1953 discovery of the molecular structure of DNA.
The Nobel Prize for the discovery of the structure of DNA was given to three scientists - James Watson, Francis Crick, and Maurice Wilkins. It was the experimental work of Wilkins and his colleague Rosalind Franklin that provided the clues to the structure. Here, Wilkins, who died in 2004, gives us his own account of his life, his early work in physics, the tensions and exhilaration of working on DNA, and his much discussed difficult relationship with his colleague Rosalind. This is a highly readable, and often moving account from a highly distinguished scientist who played one of the key roles in the historic discovery of the molecule behind inheritance.
The problem of unraveling two intertwined strands during the duplication of DNA was recognized shortly after the proposal of the DNA double helix structure in 1953. A group of enzymes called DNA topoisomerases solve this problem by breaking and rejoining DNA molecules in a controlled manner, thereby allowing strands to be passed through each other and thus untangledâ€”not just during DNA replication, but also during many other basic cellular processes. Because of their intimate involvement in the workings of the cell, topoisomerases are also the logical targets of many antibiotics (including Cipro) and anticancer agents. This book, written by James Wang, the discoverer of the first topoisomerase and a leader in the field since, presents ten chapters covering the historical backdrop of the DNA entanglement problem and the discovery of the DNA topoisomerases, how DNA topoisomerases perform their magic in DNA replication, transcription, genetic recombination and chromosome condensation, and how they are targets of therapeutic agents. The book should appeal to readers from undergraduates upwards with interests in the biological and clinical aspects of topoisomerase function, or in the mathematics and physics of topology.
DNA. The double helix; the blueprint of life; and, during the early 1950s, a baffling enigma that could win a Nobel Prize. Everyone knows that James Watson and Francis Crick discovered the double helix. In fact, they clicked into place the last piece of a huge jigsaw puzzle that other researchers had assembled over decades. Researchers like Maurice Wilkins (the 'Third Man of DNA') and Rosalind Franklin, famously demonised by Watson. Not forgetting the 'lost heroes' who fought to prove that DNA is the stuff of genes, only to be airbrushed out of history. In Unravelling the Double Helix, Professor Gareth Williams sets the record straight. He tells the story of DNA in the round, from its discovery in pus-soaked bandages in 1868 to the aftermath of Watson's best-seller The Double Helix a century later. You don't need to be a scientist to enjoy this book. It's a page-turner that unfolds like a detective story, with suspense, false leads and treachery, and a fabulous cast of noble heroes and back-stabbing villains. But beware: some of the science is dreadful, and the heroes and villains may not be the ones you expect.
Maurice Wilkins shared the 1962 Nobel Prize for Physiology or Medicine with Francis Crick and James Watson for the discovery of the double helical structure of DNA. A physicist, he worked with John Randall in the late 1930s on the development of radar, moving to the USA during World War II towork on the Manhattan project. After the War he joined Randall at King's College London and with Rosalind Franklin began an investigation into the structure of DNA. The story of Rosalind's work on the project, and her bitterness with Maurice for having given her data to Watson and Crick withouther permission, is a well-known one, and has recently been brought once again into the spotlight by Brenda Maddox's biography (published in 2002). Now, for the first time, Maurice Wilkins tells his side of the story, showing that it is not as simple as it has sometimes been portrayed.
Molecular biology is one of the great modern sciences. Headline-making developments in cloning, genetic engineering and the fight against disease all stem from the breakthrough in the 1950s and 60s of the identification of the molecule of life, DNA. This book sets out to tell the entire story of evolution: from Darwin to DNA and beyond, giving full credit to the role of quantum physics in our modern understanding of life itself, including human life.
Some mysteries were never meant to be solved - or were they? Meyer provides a fascinating glimpse into one of the newest and most intriguing areas of scientific research. Any DNA that still exists in the remains of living things after their death is called "ancient DNA''. The DNA could be from an organism that died a few days ago, or from an extinct species, such as the Australian thylacine or the New Zealand moa, or from one that died tens of thousands of years ago, such as a Neanderthal or a mammoth. That DNA can survive for such a long time is one thing, but there is much more to it than that. The study of ancient DNA has been the key to some of the most amazing discoveries. There's a whole smorgasbord of stories to sample - tales of murder, deadly disease, mysterious disappearances and even the origins of human life.
The mystery deepens and the action intensifies for 12-year-old Cruz Coronado and friends in the exciting third book in the Explorer Academy series. The adventure continues for Cruz, Emmett, Sailor, and Bryndis as they continue their studies at sea and travel to exotic locations around the world. A mysterious person alerts Cruz to impending danger while he and a few trusted pals explore ancient ruins in Petra, Jordan, and search for another piece of the puzzle his mother left behind. Worst of all, now his father has gone missing, which prompts Aunt Marisol, his number one protector, to leave the ship in search of him. Who is the new professor who takes her place? How does the new technology he introduces help or hurt Cruz's quest? Why is Nebula determined to stop Cruz before he turns 13? The clock is ticking as his first teen birthday draws near ... a milestone that will change his life forever, one way or another.
This unique look at the study of DNA goes beyond the science and explores the lives of four great scientists: James Watson, Francis Crick, Maurice Wilkins, and Rosalind Franklin. It was through their complex personal interactions and their devotion to the science that led to breakthroughs surrounding the structure of DNA and our modern understanding of genetics. Readers can learn that science is not about one individual and his or her discoveries, but is the work of many. Numerous scientific breakthroughs can be attributed to competition and rivalry.
Double Helix is a new genetic literary hybrid. Using the structure of DNA (which has its own language using paired molecules) as a model, Stephen Cain and Jay MillAr’s new book employs a sequence of speak and respond pieces to read and write their way through the alphabet and discuss everything from literature to the weather. Living in different cities for a year, the two authors kept their ongoing conversations about poetics, relationships, and culture in the early 21st century alive by writing a collaborative project over email, based on a simple alphabetic constraint. The result is Double Helix, a series of 52 micro-fictions, in which each writer meditates on a word beginning with a set letter of the alphabet. Molecular strands of concepts, arguments, and narratives twist about each other, yet also match, much like the double helix of human DNA. The final text mixes two lives, two writing styles, and two consciousnesses, that come to resemble a third mind— an act of literary meme-splicing.